Psychedelics 101

Shrooms and shroom capsules

How to Use Psychedelics

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Curious about psychedelics, but don’t know where to start? With insight from the world’s leading psychedelic experts, we’ll teach you everything you need to know to get the most out of your journey with these powerful medicines. In this course, we cover how to choose the right psychedelic for you, where to access safe, legal psychedelics, how to integrate the lessons of your trip once it’s over, and more. Psychedelics can be transformative, healing, scary, and downright magical—and while there’s no “right way” to do them, there are some harm reduction practices to ensure you’re safe and to maximize healing. Whether you’re looking to journey solo, with friends, at a retreat, or in a clinical trial, this course will help you every step of the way.

This course would not be possible without support from our sponsors, Trip.

10,000+ Students Taught
At DoubleBlind, we've teamed up with the world's leading experts to provide you with the latest, most trustworthy information on psychedelics. More than 10,000 students have graduated from our courses, and all the proceeds go back to funding our journalism to help further the psychedelic movement.
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We’ll go over basic information on how psychedelics work in the brain, why ego transcendence is so therapeutic, and what the research is saying as to why these substances are so transformative for conditions like addiction, anxiety, or PTSD.

This episode covers the basics in regard to effects, dosage, and characteristics of each psychedelic: LSD, psilocybin, MDMA, ketamine, ayahuasca, and DMT. It also includes information on questions to ask yourself in advance of tripping to help you determine which of these psychedelics might be best for you to start with.

We interviewed experts about not only the clinical research happening around psilocybin and LSD, but also to better understand why transcendent states and mystical experiences are so therapeutic. We also include information about the differences between LSD and psilocybin, what you might be able to expect during a trip, and risks or contraindications with certain medications or psychiatric conditions.

With information from Rick Doblin, executive director of MAPS (the nonprofit carrying out MDMA-for-PTSD research), we’ll go over the effects of MDMA, how it works in the brain, and why it’s so therapeutic for trauma. We’ll also go over risks, including serotonin syndrome, contraindications, and safety measures around water intake. John Saul, a study subject in MAPS trials and now a leader in psychedelic integration shares best practices for journeying with MDMA. This episode also features information on how to enroll in a clinical trial in case you may be an eligible candidate.

You might’ve heard Ketamine is showing incredible promise for treatment-resistant depression, suicidality, and trauma, among other conditions. It’s exciting because it’s the only completely legal psychedelic medicine, which means, doctors can prescribe it. But there are a lot of questions about how this works—and how to do it safely. In this episode, we speak to Dr. Jeff Becker and Dr. Erica Zelfand about the different kinds of ketamine, how much they cost, how often treatment is necessary, how to find a ketamine clinic, and, if you have treatment-resistant depression, how you might be able to get your insurance company to cover it.

In recent years, ayahuasca has become one of the most popular plant medicines for depression, trauma, alcoholism, and more. It can be intimidating though. Should you drink in a ceremony in the Amazon, at an ayahuasca church in the United States, or with an underground shaman? How do you find a safe ceremony—and how do you know if you’re even a good candidate for this experience? We speak to Chacruna founder and cultural anthropologist Bia Labate about best practices and how you can make sure you’re mindful about preserving and respecting the indigenous communities with a relationship to this medicine. In this episode, we also cover the difference between ayahuasca and DMT. Author of “DMT: The Spirit Molecule,” Rick Strassman offers his insights on dosing, journeying, and integrating this powerful molecule.


With information from integration facilitators Ido Cohen and Deanna Rogers, as well as mindfulness teacher and plant medicine guide Nate Macanian, episodes 7 through 9 offer practical advice, harm reduction information, and measures for getting to know yourself better through the psychedelic process. Before you trip (maybe for the first time), we have a number of journal prompts and questions to ask yourself about why you’re tripping, what your intention is, and how to prepare your set and setting. The more self-work and reflection you do before your psychedelic journey, the more you are likely to get out of it.

This episode covers best practices the day of the trip, including what to eat, what to do with your phone while you’re tripping, picking out music, setting up the space, and more. It also covers information on best practices, like whether or not to look in the mirror, considerations regarding whether to trip at night or during the day, and what to do in the case of a bad trip: For starters, don’t call it a “bad trip”.

Perhaps the most important episode, we’ll go over how you can get the most out of your psychedelic journey: From the initial phase in the first few days after your trip to weeks or months out, we offer best practices and journal prompts for how you can solidify the experience into your daily life and learn from it to make the changes you intended to make. We’ll also provide information on what to do if you had a challenging experience and are struggling afterward.


Why This Course?

This course was created with first-time psychonauts and those ready to go deeper in mind. We’ll walk you through picking out which psychedelic to start with, preparing for the experience, how to get through a “bad trip” (for starters, don’t call it a “bad trip”), and how to integrate the lessons afterward. We’ll also go over risks, benefits, and contraindications with other medications.

The elephant in the room when talking about psychedelics is that, well, for the most part they’re not legal. But there are some exceptions. From enrolling in a clinical trial in the U.S. to finding a trusted retreat center abroad, we point you towards safe, legal options for tripping. 

Psychedelics aren’t just about psychedelics. Whether you’re tripping with your friends in the desert or participating in a ceremony, there are so many important tools for making sure you get the most you can out of the experience. From journaling prompts and meditations to the fundamentals of integration, we give you a foundation for going deep into your own healing. 

Psychedelics can be transformative, just plain fun, or likely both. If you’re trying to use them intentionally, though, there’s a lot to consider, from the medications you’re on to your mental health history. There are also just some basic protocols for making sure you’re safe if you trip on your own, and that you know what’s in your drugs. 

We interviewed the leading doctors, scientists, and integration therapists in the field to learn how clinicians are guiding therapy—and how you can steer your own psychedelic experience in light of these best practices.

Sometimes it can be hard to seek out solid, trustworthy information about psychedelics: Traditional therapists may not know enough or be open to talking about it, while other sources on the internet may provide dubious information. We’re removing the stigma and making it easy to find useful information for cultivating your relationship with psychedelics—and yourself.

Any psychedelic trip will teach you that the experience isn’t about the drug, but about your own inner self—your mind, body, and spirit. Exploring your newfound relationship with psychedelics is an avenue to exploring your own wellness and what nourishes your soul. 

Who This Course is For

What Our Students Are Saying

What You'll Get

A video series that guides you through each step of your psychedelic journey. We’ll cover the six most popular psychedelics—LSD, MDMA, psilocybin, ketamine, DMT, and ayahuasca—with information on dosage, effects, how they function in the brain and body, how to prepare for your trip, how to integrate it, and some best practices for during your trip.

Information regarding clinical psychedelic research to help inform your decision in light of the healing potential of each medicine.

A written companion to the video course with extensive information on data from clinical trials and resources to help you learn more about the therapeutic and spiritual uses of psychedelics, as well as harm reduction practices.

Additional trusted resources for support and learning including a list of psychedelic integration therapists, and how to find a psychedelic community in your city.

  • Choosing which psychedelic to start with
  • Preparing for your trip
  • Cultivating your set and setting
  • Getting through a “bad trip” (don’t call it a “bad trip”)
  • Integrating the lessons of your journey

LIZ, How to Use Psychedelics Student

It's really amazing to go into these trips armed with what you can expect

"This course sets you up to intentionally be able to use these psychedelics as part of the growth process, which I just think is really amazing and inspiring. I'm really grateful I did this course and I really recommend it to anyone who is interested in growing and using psychedelics in that journey."
LIZ, How to Use Psychedelics Student

It's really amazing to go into these trips armed with what you can expect

"This course sets you up for to intentionally be able to use these psychedelics as part of the growth process, which I just think is really amazing and inspiring. I'm really grateful I did this course and I really recommend it to anyone who is interested in growing and using psychedelics in that journey."

Frequently Asked Questions

This course is for beginner psychonauts, including people who have never tried a psychedelic, as well as those who want to deepen their relationship with psychedelics and use them with intention and/or for personal growth.

The course is now open and is designed for you to move through at your own pace. The materials, including the episodes and written guide, will be available to you forever.

Once you buy the course, all of the materials can be accessed online with a username and log-in through our website.

Yes, you can watch the episodes as many times as you’d like.

Yes, we’ve had people from all over the world take the course! Our community is very global.

No, sorry. Psychedelics are illegal in most of the world, including the United States, so we can’t tell you where to get them. But we will provide you with vital information to help you stay safe.

It’s important to us that people have access to the resources they need to heal. We have limited scholarship opportunities. Email us at: [email protected]

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